THE WALDMAN LAB
Institute for Biomedical Engineering, Science and Technology (Ryerson University and St. Michael's Hospital)
Department of Chemical Engineering (Ryerson University)
Cartilage Tissue Engineering
Cartilage is a dense, load-bearing connective tissue found in many parts of the body. In joints, articular cartilage serves to not only to transmit the compressive joint loads to the underlying subchondral bone but, also to provide a low-friction interface between the contacting cartilage surfaces of the joint. Alternatively, the elastic cartilage of the outer ear is a flexible tissue that amplifies and directs sound to the auditory canal. A major clinical problem is that once cartilage is damaged, either by trauma or disease, tissue function can be permanently affected as cartilage generally has a limited capacity for repair in adults. As the few surgical techniques available to repair or reconstruct cartilage have not proven to be entirely successful, efforts have focused on tissue engineering methods to create suitable tissue for implantation.
Our research group focuses on the engineering of functional cartilage constructs suitable for joint resurfacing, spine repair, ear and tracheal reconstruction through the use of bioreactors and mechanical stimuli to guide tissue growth as well as the development of patient-specific constructs that can be tailored to anatomy of the implantation site.
Through a combination of non-invasive imaging, 3D modelling, and rapid prototyping we are developing patient-specific tissue engineered cartilage grafts which match the anatomy of the defect site for joint resurfacing.
Anatomically shaped cartilaginous ear constructs developed for patients suffering from microtia or cancer.
We use mechanical stimulation as a method to enhance the growth and properties of our engineered tissues. In addition, we investigate specific pathways in which cells sense and respond to mechanical stimuli.
Cartilaginous tubes lined with a respiratory epithelium for trachea repair and/or reconstruction.
Anatomically shaped cartilage grafts for nasal-septal repair and/or reconstruction.
Injectable biological scaffolds for disc repair and regeneration.
Post Doctoral Research Associate
We are seeking an enthusiastic, self-motivated researcher who has just recently completed their PhD program (ideally within the past 2 years). Qualified candidates should hold a Ph.D. in biomedical engineering, chemical engineering, cell biology, biochemistry or a related field with relevance to tissue engineering. The desired skills include: cell culture, biochemistry, molecular biology and biomechanics. In addition, the ability to write and present research results, and assist in the development of future granting proposals are strongly sought. The position is available immediately for a one-year contract which is renewable depending on the performance of the candidate and the current funding situation.
Interested individuals should send a current curriculum vita, a brief statement of research interests, and the names and contact information of at least two references to Dr. Stephen Waldman.
Graduate Students (PhD and Masters)
We are always seeking enthusiastic, self-motivated graduate students at either the Masters or PhD level. Qualified candidates should have a background in biomedical engineering, chemical engineering, cell biology, biochemistry or a related field with relevance to tissue engineering. Interested individuals should send a current curriculum vita and a brief statement of research interests to Dr. Stephen Waldman.
Ryerson University has an employment equity program, welcomes diversity in the workplace and encourages applications for all qualified candidates including women, aboriginal peoples, persons with disabilities, and racial minorities.
Dr. Waldman's Office:
Department of Chemical Engineering
Faculty of Engineering & Architectural Science
Kerr Hall South, KHS 241N
Toronto, Ontario, Canada M5B 2K3
416.979.5000 x 4200
Li Ka Shing Knowledge Institute
7W2 - 209 Victoria St.
St. Michael's Hospital
30 Bond Street
Toronto, Ontario, Canada M5B 1W8